USMLE Step 1 (USMLE-STEP1-2026/S1)
Official
system11
| Category | Published share |
|---|---|
| Human Development | 1–3% |
| Blood & Lymphoreticular/Immune Systems | 9–13% |
| Behavioral Health & Nervous Systems/Special Senses | 10–14% |
| Musculoskeletal, Skin & Subcutaneous Tissue | 8–12% |
| Cardiovascular System | 7–11% |
| Respiratory & Renal/Urinary Systems | 11–15% |
| Gastrointestinal System | 6–10% |
| Reproductive & Endocrine Systems | 12–16% |
| Multisystem Processes & Disorders | 8–12% |
| Biostatistics & Epidemiology/Population Health | 4–6% |
| Social Sciences: Communication and Interpersonal Skills | 6–9% |
discipline11
| Category | Published share |
|---|---|
| Pathology | 45–55% |
| Physiology | 30–40% |
| Nutrition | 15–20% |
| Gross Anatomy & Embryology | 10–20% |
| Microbiology | 10–20% |
| Pharmacology | 10–20% |
| Behavioral Sciences | 10–15% |
| Biochemistry | 5–15% |
| Histology & Cell Biology | 5–15% |
| Immunology | 5–15% |
| Genetics | 5–10% |
competency4
| Category | Published share |
|---|---|
| Practice-based Learning & Improvement | 4–6% |
| Communication and Interpersonal Skills | 6–9% |
| Patient Care: Diagnosis | 20–25% |
| Medical Knowledge | 60–70% |
Readiness on this exam shows blueprint coverage and predicted recall only.
Source: USMLE Step 1 Content Outline and Specifications, retrieved 2026-11-02 · https://www.usmle.org/exam-resources/step-1-materials/step-1-content-outline-and-specifications
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